The E! News anchor's G by Giuliana collection will be sold exclusively on HSN, hsn.com and HSN Mobile.
She told People: "It's super affordable, easy to just wear. I'll be wearing it on my shows. I think people are really going to like it."
Rancic said that she was inspired to venture into fashion by her father, who was a master tailor in Naples, Italy.
"He's always had clothing stores and had men's and women's clothing, so I've always had fashion running in my veins," the star added.
"But I'm not crazy, not delusional; I didn't try to do a line and sell it to the top department stores with a crazy price tag. I just wanted something that everyone could get."
Rancic can be seen in the fifth season of her reality show Giuliana & Bill on Tuesdays at 8pm and 11pm ET on the Style Network.
Watch the trailer for Giuliana & Bill below: