The cartoonist's ongoing Vertigo series will end with a double-sized issue #40 in December.
"So why end it now?" Lemire wrote on Vertigo's official blog. "I want to make one thing really clear... Sweet Tooth is not being canceled.
"The decision to end it at #40 is entirely my choice. Truth is, I always knew what the ending of Sweet Tooth would be. It was one of the first ideas I came up with when writing the pitch for the book.
"The beginning and the end of this story were always pretty much written in stone, it was the middle bit that was fluid, and grew and changed as I went along. So, for me it's incredibly gratifying to finally get to the end of the journey with Gus and Jepperd.
"Everything I've done with the series so far, everything I've built month after month, has all been about this, the final story."
Lemire is currently writing Animal Man for Vertigo's parent company DC Comics and is in the process of transferring from Frankenstein: Agent of S.H.A.D.E. to Justice League Dark.