The singer was unable to reveal the names of the artists involved, but confirmed that they are both based in America.
Watch Ed Sheeran discussing his upcoming collaborations at the Brit Awards 2012 below:
He said: "[There are] two really big ones who I can't say yet, though it's just been confirmed for the album.
"One of them is probably the biggest rapper of our generation and the other one is a big rapper as well."
Sheeran picked up prizes for 'Best Male' and 'Best Breakthrough' at this year's Brits.
The star recently described the ceremony as the best night of his life.
> Stars reveal their favorite Brits moments - One Direction, Ed Sheeran, more
> Brit Awards 2012 in 90 seconds - video
Watch Ed Sheeran perform 'Lego House' at the Brit Awards below:
See pictures from the Brits below: