The singer revealed that she has teamed up with the punk rock star after tweeting a picture of them both in a recording studio.
She said: "its a fk!ng dream come true to be collaborating w my IDOL! the original WILD CHILD. Iggy + I got a song for yall on my next record…get ready".
The star recently unveiled her collaboration with Flaming Lips on '2012 (You Must Be Upgraded)' and has discussed working with Justin Bieber and Keith Richards for her new record, which is due later this year.
Ke$ha previously described the sound of her sophomore album as "c**k pop", adding: "This is the dawn of a new genre of music."
Watch the music video for Ke$ha's 'Animal' below: