Pyle - who played Constance in the Oscar-winning film - will play a lead role in the project, according to Deadline.
Glee's Mike O'Malley has written and will also star in Prodigy Bully, which follows Audie Murphy, a young boy genius who uses his brains and brawn to manipulate others.
Pyle, who has recently appeared on Two and a Half Men and The Mentalist, will portray Audie's mother Celeste, while O'Malley will play his father.
The role of Audie is yet to be cast, though 90210's Hayley Holmes has signed up to play the boy's sister.
Cody Sullivan will play the gifted and wealthy Colby, a student at Audie's school, while Ysa Penajero has been cast as Heather Kwitkowski-Welch, another student who catches Audie's eyes.
Southland's John Wells will also work on the pilot, having previously worked with O'Malley on Showtime's Shameless.
O'Malley and Wells will be joined as executive producers by Glee director Paris Barclay and Andrew Stearn.
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Watch the trailer for The Artist below: