The NBC project, which has the working title DILFs, will focus on a trio of young fathers who struggle to adjust to adult life.
Sopranos star Sigler will play the wife of one of the three leads, according to Deadline.
Her husband will be portrayed by the previously-cast Zach Cregger, best known for his role on NBC's short-lived sitcom Friends with Benefits.
Sigler has also appeared on Ugly Betty, How I Met Your Mother and played a fictionalised version of herself on Entourage.
Written and executive produced by The Office scribe Charlie Grandy, the Fallon pilot will be helmed by 2 Broke Girls director Scott Ellis.
Other NBC comedy pilots in contention for a series pick-up include Dane Cook's Next Caller Please and Lady Friends starring Minnie Driver and Andrea Anders.
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