The actor would appear opposite Famke Janssen in the horror drama, reports Deadline.
Based on a forthcoming novel by Brian McGreevey, Hemlock Grove follows the investigation into the murder of a young girl.
Scott would play the brother-in-law of Olivia (Janssen), the controlling 'dame' of the eponymous grove.
The Scottish star is known for his roles in films such as 2000's Mission: Impossible II and last year's My Week with Marilyn. He also appeared on ABC's Desperate Housewives between 2006 and 2007.
Landon Liboiron (Terra Nova) and Bill Skarsgard (Anna Karenina) are also attached to Hemlock Grove, while Eli Roth (Hostel) will executive produce.
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