Laurie helmed the show's next episode, which centres on Leonard's character Wilson in the aftermath of his cancer diagnosis.
"Given the fact that it's an episode where I have a bunch of serious stuff to do, and some big scenes, I'm comforted to know that the director is someone I know pretty well," Leonard told TVLine.
He went on to suggest that it can be preferable to have a fellow actor on the show behind the camera, as opposed to a jobbing director.
"They're one of you, so they're directing the show they're going to be working on next week and the week after," he explained.
"So there is a level of intensity and attention and care that's sometimes lacking in other directors."
Watch the promo for the next episode of House below:
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Leonard also commented on viewers' affection for the House/Wilson relationship.
"I'm glad that Hugh's and my work together has meant something special to people," he said.
"That does infuse the love of getting to work and doing it, and helps to support those days when you're kind of tired or down. I know how powerful that is, when you love a television show. But when it's your own show, it's different.
"It's like when someone says 'Hey, your sister's hot', and you're like... 'What? What are you talking about?'"
Laurie recently said that he felt "a tremendous responsibility" to do Leonard justice in the episode, which airs this Monday (April 30) in the US.